Abstract
In the present work, testosterone-loaded alginate nanocapsules were prepared by in situ nanoemulsification-polymer cross-linking method. Drug loading, particle size (diameter), polydispersity index and zeta potential of these alginate nanocapsules were measured 30.22±1.90%, 34.53±1.72nm, 0.22±0.04 and −5mV, respectively. The pharmacokinetic evaluation of these nanocapsules was also performed in female Sprague Dawley rats. Cmax, Tmax and AUC0–24 vales were estimated 38.63ng/ml, 2h and 317.93ngml−1h−1, respectively. The pharmacokinetic result of testosterone-loaded alginate nanocapsules indicates better bioavailability in comparison with pure testosterone and commercial testosterone injection.
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