Abstract
The plasma concentration time profiles for nicotine were characterized after a single application of nicotine transdermal system to the upper fore arm of healthy smokers. A 12 cm2 system was applied for 24 h. Blood samples were withdrawn at predetermined time intervals. Plasma nicotine concentrations rose rapidly and achieved a mean Cmax value of 14.5 ng/ml .The half life was estimated as 4.78 h and AUC(0-24)181.0 ng.h/ ml. The nicotine transdermal system was well tolerated. The results indicate that the system has potential usefulness in smoking cessation. The pharmacokinetic profiles of marketed patch system was compared with the developed system. Significant difference was observed in the pharmacokinetic parameters.
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