Pharmacokinetic drug-drug interactions: an insight into recent US FDA-approved drugs for prostate cancer.

Abstract

Pharmacokinetic drug-drug interaction is a significant safety and efficiency concern as it results in considerable concentration changes. Drug-drug interactions are a substantial concern in anticancer drugs that possess a narrow therapeutic index. These interactions remain as the principal regulatory obstacle that can lead to termination in the preclinical stage, restrictions in the prescription, dosage adjustmentsor withdrawal of the drugs from the market. Drug metabolizing enzymes or transporters mediate the majority of clinically relevant drug interactions. Cancer diagnosed aged patients use multiple medications and are more prone to significant drug-drug interactions. This review provides detailed information on clinically relevant drug-drug interactions resulting from drug metabolism by enzymes and transporters with a particular emphasis on recent FDA approved antiprostate cancer drugs.