Abstract
1. The pharmacokinetic and residue elimination patterns of sulphachloropyridazine appear to be modified by disease, even without affecting key organs essential for drug metabolism. 2. Drug kinetics and residue elimination data of a sulphachloropyridazine-trimethoprim preparation were compared using infectious coryza-affected (IC) fowl and healthy chickens. 3. The plasma concentrations of sulphachloropyridazine and trimethoprim were higher in affected animals, hence a reduced volume of distribution was obtained. 4. The half-life of sulphachloropyridazine and trimethoprim was reduced in IC-affected fowl and body clearance values were decreased. 5. The rate of drug residue elimination was noticeably slower in the IC-affected group. 6. These results indicate that drug elimination patterns in healthy and diseased animals are not the same.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
