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Abstract
The current study was aimed at assessing an impact of oxidative phenotype on intensity of pharmacodynamics effect after applying a combination anti-hypertensive therapy in patients with high- and very high-risk arterial hypertension. It was confirmed that the level of decrease arterial pressure directly correlated with oxidative phenotype. Upon that, patients with slow oxidative phenotype administered with a fixed- vs. free-combination of amlodipine and lisinopril (Equator) exhibited significantly more pronounced anti-hypertensive effect.
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