Pharmacognostic Study, Phytochemical Screening and Neuroprotective Activity of Methanolic extract of Gynandropsis gynandra against Transient Global Ischemia induced brain damage in rats

Abstract

Gynandropsis gynandra is found to contain flavonoids which are proven to be potent neuroprotective agents which could cross blood brain barrier easily and treat neurotoxicity. Neurons get damaged easily because of our current lifestyle which includes usage of gadgets, smartphones etc causing memory loss, degraded cognitive thinking and other disorders like stroke. The best way to treat or prevent this is intake of flavonoids which have protective effect. The aim of the work was to assess protective effect of methanolic extract of whole herb of Gynandropsis gynandra against cerebral ischemia induced brain damage in albino wister rats. Pharmacognostic studies and phytochemical screening was carried out using standard methods. Cerebral ischemia was induced by occluding carotid artery using nylon thread followed by reperfusion. Animals were sacrificed and immediately brains were isolated and analysed for various biochemical parameter estimation, brain infarct area and histopathological studies. Biochemical estimations were measured and results were expressed in terms of Mean ± SEM by using ANNOVA software. Pharmacognostic study gave relevant information about ash values and Extractive values. Methonolic extract of Gynandropsis gynandra have proven to have protective effect. Of all the three doses, 300mg/kg dose of the drug have shown maximum protective effect when compared to other two doses.