Abstract
The term “pharmacogenetics” was coined in the 1950s to describe inherited differences in the disposition and effects of medications and other xenobiotics. Pharmacogenetic studies have focused largely on inherited variations in drug metabolism and polymorphisms of the genes encoding drug-metabolizing enzymes, to elucidate the molecular basis of these variations (Nebert 1997). Although genetic polymorphism in drug metabolism remains a primary focus, inherited differences in drug targets (e.g., receptors, genetic subsets of diseases, etc.) represent another facet of pharmacogenetics that can be of equal importance in determining the effects of some medications.
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