Abstract
Aim. To analyze pharmacotherapy of cerebral infarction in patients with atrial fibrillation (AF) in real clinical practice of neurological departments of Saratov hospitals. Material and methods. A retrospective longitudinal pharmacoepidemiologic study was carried out. Medical cards were analyzed in patients with cerebral infarction and atrial fibrillation treated in neurology departments from 01.01.2009 to 31.12.2011. Results. Acetylsalicylic acid was prescribed to 66.7% of patients, warfarin – 3.9%. At that target level of international normalised ratio was reached only in 40% of patients. It has been shown frequent (96%) prescriptions of metabolic, neuroprotective and vasoactive drugs with low level of efficacy evidence. Beta-blockers (in 39.3% of patients) and their combination with digoxin (18.7%) were prescribed for heart rate control. Conclusion. Generally, in real clinical practice doctor’s choice of pharmacotherapy of cerebral infarction in patients with AF is not exactly in line with contemporary guidelines. These patients are frequently prescribed drugs with low efficacy and level of evidence.
Highlights
At that target level of international normalised ratio was reached only in 40% of patients. It has been shown frequent (96%) prescriptions of metabolic, neuroprotective and vasoactive drugs with low level of efficacy evidence
Гусева Е.И. (2009); АCC/AHA/ESC(2006); Клинические рекомендации по диагностике и лечению пациентов с фибрилляцией предсердий (2010)] [1, 5,6,7,8,9,10,11]
Перенесенный инсульт зарегистрирован у 31 человека (24%), хроническая ишемия головного мозга – у 67 (51,9%), атеросклероз – 110 (85,3%), гиперхолестеринемия – у 73 (56,6%), сахарный диабет (СД) 2 типа – у 19 (14,7%), ожирение – у 17 больных (13,2%)
Summary
Анализ сложившейся практики лекарственной терапии инфаркта мозга на фоне фибрилляции предсердий (ФП) в неврологических отделениях стационаров Саратова. Aim. To analyze pharmacotherapy of cerebral infarction in patients with atrial fibrillation (AF) in real clinical practice of neurological departments of Saratov hospitals. In real clinical practice doctor’s choice of pharmacotherapy of cerebral infarction in patients with AF is not exactly in line with contemporary guidelines These patients are frequently prescribed drugs with low efficacy and level of evidence. Лечение больных инфарктом мозга на фоне ФП является актуальной и сложной проблемой клинической неврологии, кардиологии и фармакологии, имеющей существенное социальное значение [1,2,3]. Цель исследования: провести анализ сложившейся практики лекарственной терапии инфаркта мозга на фоне ФП в неврологических отделениях стационаров г. Гусева Е.И. (2009); АCC/AHA/ESC(2006); Клинические рекомендации по диагностике и лечению пациентов с фибрилляцией предсердий (2010)] [1, 5,6,7,8,9,10,11]
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