Abstract

Objective To observe the therapeutic effect of bismuth potassium citrate tablets(BPCTs) on gastritis and gastric ulcer.Methods Using rat foot swelling,cotton pellet granuloma test,mouse writhing test and hot plate test,we observed the anti-inflammation and analgesic effects of BPCTs.The acute gastritis,gastric ulcer and chronic gastritis models were established with rats and mice;the gastric juice amount,gastricacidity(pH value),pepsin activity,and ulcer index were determined,and the pathological changes were observed,so as to evaluate the therapeutic effects of BPCTs on various kinds of gastritis and gastric ulcer.Results The high-,medium-and low-dose BPCTs(0.44,0.22 and 0.11 g/kg) significantly decreased paw swelling in rats compared with the control group(P0.05 or P0.01),and the high-and medium-dose also significantly relieved granuloma(P0.01),reduced writhing times(P0.05),elevated the pain threshold(P0.05),decreased the ulcer indices and ulcer area(P0.05 or P0.01),and inhibited the decrease of gastricacidity in chronic gastritis and bile reflux gastritis(P0.05).Pathological examination showed high-,medium-and low-dose BPCTs significantly improved the pathological changes of chronic gastritis and gastric bile reflux of gastritis.Conclusion BPCTs have a therapeutic effect for acute gastritis,gastric ulcer,chronic gastritis and bile reflux gastritis.

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