Abstract
The vascular endothelium plays a predominant role in the response of tumors and normal tissues to ionizing radiation. PDGF receptor β and VEGF receptor 2 are localized within the host component of tumors. To determine the pharmacodynamics and biodistribution of TKIs, we studied immunohistochemistry and proteomic response to TKIs in tumor bearing mice. Reduced tumor blood flow results in reduction in tumor perfusion with nutrients and oxygen. We studied the kinetics of tumor blood flow, oxygenation, glycolysis and ATP levels in tumors to determine whether depleted cancers have altered response to radiation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Radiation Oncology*Biology*Physics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
