Abstract
Sedatives are powerful tools to study consciousness, allowing investigators to manipulate brain states and associated neurophysiological markers. Conscious states are typically inferred through responses to external stimuli such as auditory tasks and noxious stimulation. The use of an auditory task to probe loss of responsiveness (LOR) during dexmedetomidine sedation previously yielded a mean (standard deviation [sd]) effect-site concentration (Ce) of 2.06 (0.66) ng ml–1 at LOR.1 Here, we report a stimulus-free behavioural paradigm to assess conscious states during titration of dexmedetomidine.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
