Abstract
Rupatadine, a new antihistamine with dual antagonistic activity against platelet-activating factor (PAF) and histamine H1 receptors, can inhibit inflammatory reactions by affecting allergic reactions at different stages. It has a rapid onset of action and a long-lasting effect, so once-daily dosing is recommended. Clinical studies have shown that low-dose oral rupatadine can effectively control the symptoms of seasonal and perennial allergic rhinitis. Recent researches have demonstrated that it has good effect on some skin diseases such as chronic idiopathic urticaria and cold urticaria with good tolerability. Key words: Urticaria; Histamine agents; Pharmacologic actions; Therapeutic uses; Safety
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