Pharmacodynamic Mechanisms of the Development of Pulmonary Fibrosis Due to Amiodarone use

Abstract

Introduction: Amiodarone is a benzofuran derivative with highly effective class III antidysrhythmic activity used in ventricular and supraventricular arrhythmia; however, its most side effect is pulmonary toxicity, with an incidence of 0 to 10%, and a mortality of 1 to 33%. The mechanism of the adverse reaction is still a matter of investigation. Therefore, the overall objective of this study is to determine the time in which pulmonary fibrosis develops from the use of amiodarone, which we hope to obtain with the following research question: What is the time in which pulmonary fibrosis develops from the use of amiodarone? Discussion: based on the sources reviewed, these establish that there is a risk of developing pulmonary adverse reactions from the therapeutic use of amiodarone directly related to the serum concentrations of the drug, but complete these data with broader populations. Conclusions: We were able to determine from the literature review that lung injury can be activated by low and high therapeutic doses of amiodarone.