Abstract
Ethacrynic acid is an extremely potent diuretic and natriuretic agent. Its rapid onset of action following intravenous administration suggests particular usefulness in patients with severe cardiac decompensation, e.g., acute pulmonary edema. Furthermore, the parenteral drug appears to be effective despite reduced glomerular filtration rates, and, therefore, may be useful in the treatment of edema associated with advanced renal functional impairment. Oral administration of ethacrynic acid also results in potent diuretic activity, with substantial antihypertensive effectiveness as well. The oral compound compares favorably with other potent oral diuretics and with parenteral meralluride.
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