Pharmaco-modulation of inflammatory response induced by the Kv1.3 channel ligands

Abstract

Background: Voltage-dependent potassium channels (Kv1.3), play a key role in a wide variety of physiological processes, including immunity, metabolism and axonal targeting in addition to its main role in the stabilization of the resting potential. Binding of neurotoxin isolated from scorpion venom to its target, the Kv1.3 channels, is able to alter neuronal excitability leading to neurological disorders, accompanied by inflammatory response. In the brain insulin receptor kinase is able to modulate the activity of a predominant voltage-gated channel by tyrosine phosphorylation at multiple sites of the amino and carboxyl terminus of Kv1.3 channel.