Abstract
ObjectivePolypharmacy and potentially inappropriate medications (that is, those associated with an unfavorable risk-benefit ratio) are common concerns in the context of elderly patients treated in primary care as they may increase the risk of morbidity and mortality, as well as healthcare costs. Several studies have assessed the impact of pharmacist-led systematic reviews with respect to prescription appropriateness, health outcomes and/or costs. However, no cluster-randomized controlled trial has been identified that provides an overall assessment of these variables. The objective is to determine the effectiveness of a pharmacist-led systematic medication review in reducing the mean number and proportion of patients on potentially inappropriate medications (primary goal); as well as in decreasing morbidity and mortality and the cost of medications and the use of healthcare resources (secondary goals). MethodAn open-label, cluster-randomized controlled trial will be conducted; where primary care physicians will be randomized either to receive (intervention group) or not to receive pharmacist recommendations to withdraw potentially inappropriate medications detected through the combined use of explicit and implicit criteria (control group). Primary endpoints will be the proportion of patients on potentially inappropriate medications and the mean number of such medications per patient. Secondary endpoints will be healthcare resources used, the proportion of patients who die and the mean number of days survived, as well as the cost of medications and cost of healthcare resources used. ConclusionsIn line with similar reports and based on our stud's design, we hope to obtain statistically significant reductions in the use of potentially inappropriate medications and in medication costs overall. We do not however expect to obtain significant reductions in morbimortality or the cost of health resources employed.
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