Pharmaceuticals Through Enzymatic Transesterification and Enzymatic Aminolysis Reactions

Abstract

Biotransformations are now accepted as a methodology for the preparation of fine chemicals. The majority of enzyme-catalysed reactions involve the use of hydrolases, especially lipases, in hydrolysis or transesterification reactions. Over the last few years, other interesting processes have appeared, not only with hydrolases but also with oxidoreductases and oxynitrilases. However, the use of lipases in organic solvents proves an excellent methodology for the preparation of single-isomer chiral drugs by enzymatic transesterification and aminolysis reaction.