Abstract

An existing drug in the conventional dosage form is evolution in to novel drug delivery system which can significantly enhances and improves the performance of drug in terms of drug safety, drug efficacy as well as patient compliance. With the help of appropriate novel approaches, an existing drug molecule can get a new life and can be a major advance solution for the problems towards the release of drug at specific site and specific rate. The main aim of novel drug delivery system is to minimize the drug loss and drug degradation which can be achieved by targeting the drug to the site of interest. With the help of soluble or insoluble biodegradable natural and synthetic polymers different novel formulations can be formulated as microparticles, microcapsules, liposomes, neosomes, micelles etc. Targeting is based on active targeting and passive targeting mechanisms for drug release. This review covers the basic information on Novel Drug Delivery Systems (NDDS).

Highlights

  • Novel Drug delivery System (NDDS) refers to the system which helps in transporting a pharmaceutical compound in body which can safely achieve its desired therapeutic effects

  • It involves site-targeting within the body, or facilitating systemic pharmacokinetics; in any case, it is typically concerned with both quantity and duration of presence of drug and it is advanced drug delivery system which improves drug potency, drug release to provide a sustained therapeutic effect, provide safety, drug can be targeted to a specific site

  • The scientists use to alter the therapeutics of drug by altering the drug pharmacodynamics but in novel drug delivery system the therapeutics of drug based on altering the pharmacokinetics of the drug by using different methods

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Summary

Passive targeting

The natural course of bio-distribution of the carrier is employed. Microencapsulation process convert the liquids to solids, changing the colloidal and surface properties, providing environmental protection and controlling the release characteristics of different coated materials Some of these properties can be achieved by micro packaging techniques but in microencapsulation the small coated particles are used to make a wide variety of dosage forms and have not been feasible. The controlled released dosage forms are so designed and formulated as having the sustained action, sustained release, prolonged action, delayed action and timed release medication This has been done by developing the new drug entities, discovering of new polymeric materials that are suitable for prolonging the drug release, safety, improvement in therapeutic efficacy.

Oral osmotic pump
CONCLUSION
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