Abstract
Astragalus is a popular Materia Medica in China, and it could be applied in the treatment of various diseases. It contains a variety of chemically active ingredients, such as saponins, flavonoids, and polysaccharides. Plant-derived bioactive chemicals are considered natural, safe, and beneficial. Among the infinite plant-identified and isolated molecules, flavonoids have been reported to have positive effects on human health. Calycosin is the most important active flavonoid substance identified predominantly within this medicinal plant. In recent years, calycosin has been reported to have anticancer, antioxidative, immune-modulatory, and estrogenic-like properties. This review collected recent relevant literatures on calycosin and summarized its potential pharmaceutical properties and working mechanism involved, which provided solid basis for future clinical research.
Highlights
Introduction e development of traditional Chinese medicine (TCM) has a history of thousands of years, and it has accumulated myriad medical experience and summarized pharmacological effects of Materia Medica playing a pivotal role in modernization of traditionalChinese medicine (TCM) [1, 2]
Plant-derived chemicals are associated with drug development, such as Taxol isolated from Taxus chinensis and camptothecin identified and enriched from Camptotheca acuminata
Fang group found that calycosin could modulate GSK-3β pathway for stimulating osteoblast differentiation which was further confirmed by its specific inhibitor GSK1904529A after revealing alkaline phosphatase (ALP), Col1a1, and Runx2 expression levels [54]
Summary
Chen group (2014) confirmed that calycosin induced ER+ MCF-7 cell apoptosis via the blocking insulin-like growth factor 1 receptor (IGF-1R) pathway after 48-hour treatment [18]. Wang found that calycosin inhibited colorectal cancer proliferation and migration by enhancing BATF2 to target plasminogen activator inhibitor-1 [27] This molecule was able to abolish transforming growth factor ß(TGF-β-) induced epithelial-to-mesenchymal transition via altering Wnt mechanism [27]. Reduced cell migration and invasion; enhanced apoptosis rate via blocking IGF-1R pathway; downregulated VEGF and MMP Downregulation of Rab27B and β-catenin Abnormal expression levels of ERα, ERβ, ATP-binding cassette subfamily G member 2, breast cancer type 1 susceptibility protein, p450, and EGFR Colorectal cancer proliferation Beclin-1 and LC-3II overexpression Upregulation of ERβ and PTEN Induced osteosarcoma apoptosis and decrease MMP2. ERK1/2 and NF-κB pathways were involved and evidenced by Kim et al and Cheng et al after calycosin presence for 4 hours [47, 48]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Evidence-based complementary and alternative medicine : eCAM
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
