Abstract

We present the results of terahertz pulsed imaging (TPI) experiments to measure the `hardness' of pharmaceutical solid dosage forms (tablets) compacted at various compression forces. Results of TPI measurements are compared to those from diametric compression tests as well as finite element analysis (FEA) simulations of density distributions on the surface of the tablet. In both cases strong correlation with TPI results was found. In particular, radially symmetric spatial distributions in tablet density due to the shape of the punch used in tablet manufacture were observed. The results of these experiments show that TPI is suitable for non-destructive monitoring and control of pharmaceutical manufacturing processes.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.