Pharmaceutical prospects of biosurfactants produced from fungal species.

Abstract

The development of novel types of biogenic surface-active compounds is of greater interest for combating many diseases and infections. In this respect research and development of biosurfactant has gained immense importance. Substantially, biosurfactant is defined as a class of active amphiphilic chemical compounds that comprise hydrophobic and hydrophilic moieties on their surfaces. It is generally known that many kinds of microorganisms can be used to produce these surfactants or surface-active compounds. Hosting interesting features such as biodegradability, emulsifying/de-emulsifying capacity, low toxicity, and antimicrobial activities; these amphiphilic compounds in recent years have flourished as an ideal replacement for the chemically synthesized surfactant, and also have various commercial attractions. Both bacteria and fungi are the producers of these amphiphilic molecules; however, the pathogenicity of certain bacterial strains has caused a shift in interest toward fungi. Therefore, various fungi species have been reported for the production of biosurfactants amongst which Candida species have been the most studied strains. Biosurfactants uphold desired properties like antibacterial, antifungal, antiviral, antiadhesion, and anticancer activity which proves them an ideal candidate for the application in various fields like pharmaceutical, gene therapy, medical insertion safety, immunotherapy to fight against many chronic diseases, and so forth. Hence, this review article discusses the pharmaceutical prospects of biosurfactants produced from different fungal species, providing new directions toward the discovery and development of molecules with novel structures and diverse functions for advanced application in the medical field.