Abstract
The flow-injection method is applied as a means of decreasing the work load associated with repetitive control determinations. The system described utilizes the design concepts used in post-column reaction with spectrophotometric detection in high-performance liquid chromatography. This equipment allows for minimal set-up and change-over time between samples and also provides the high accuracy and precision required in a testing laboratory. The system is applied to dissolution samples of hydrochlorothiazide and timolol maleate, and to combination tablets of hydrochlorothiazide, methyldopa and amiloride. Samples can be quantified at rates of up to 1200 h −1.
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