Abstract

A suitability of two different liquid phantoms of blood-glucose solutions as phantoms for development of microwave sensors for noninvasive blood glucose monitoring is compared. The two phantoms are physiological saline-glucose and pig blood-glucose solutions. For this purpose a simple microwave sensor is developed for in vitro monitoring of blood glucose levels. The sensor consists of a microstrip antenna and of a small rectangular container on the top of the antenna. The container is filled with one of the liquid phantoms. Both phantoms with different glucose concentrations ranging from 0 to 500 mg/dL are considered. Dependence of sensor’s resonant frequency on glucose concentration of LUTs is both estimated by aid of numerical simulations and measured. The results are discussed and compared with some results reported in the literature.

Highlights

  • In 2014, 382 million people (8.3% of the overall population) have diabetes and it is expected that up to year 2035 the number of people with diabetes will rise to 592 million

  • More than 11% of healthcare spending worldwide is on treatment of diabetes [1]

  • Regular blood glucose monitoring by diabetes patients would both significantly improve their quality of life and decrease the diabetes-treatment cost

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Summary

Introduction

In 2014, 382 million people (8.3% of the overall population) have diabetes and it is expected that up to year 2035 the number of people with diabetes will rise to 592 million. With respect to development of an electromagnetic noninvasive glucose monitoring system some authors report dielectric properties of physiological saline-glucose [6] and of blood plasma-glucose solutions [7, 8]. One of the main aims of this paper is to show, both by numerical simulation results and by measurement results, that there are significant differences between dielectric properties of physiological saline-glucose and blood-glucose solutions. A simple microwave sensor based on microstrip (MS) patch antenna principles is developed for in vitro blood glucose level monitoring. The sensor was modeled and fine-tuned, in International Journal of Antennas and Propagation order to obtain low reflection coefficient at the resonant frequency, in COMSOL Multiphysics [14] For both numerical simulations and measurements two LUTs were considered, physiological saline-glucose and blood-glucose solutions, with different glucose concentrations. The sensor was manufactured and the shift of the resonant frequency of the antenna was both measured and simulated for both considered glucose solutions

LUTs: Models of Their Dielectric Properties and Preparation
Numerical and Measurement Results and Discussion
Findings
Conclusions and Outlook
Full Text
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