Abstract
Neutrophils are crucial elements of innate immune system, which assure host defense via a range of effector functions, such as phagocytosis, degranulation, and NET formation. The latest literature clearly indicates that modulation of effector functions of neutrophils may affect the treatment efficacy. Pharmacological modulation may affect molecular mechanisms activating or suppressing phagocytosis, degranulation or NET formation. In this review, we describe the role of neutrophils in physiology and in the course of bacterial and viral infections, illustrating the versatility and plasticity of those cells. This review also focus on the action of plant extracts, plant-derived compounds and synthetic drugs on effector functions of neutrophils. These recent advances in the knowledge can help to devise novel therapeutic approaches via pharmacological modulation of the described processes.
Highlights
Reviewed by: Anderson Guimarães-Costa, Federal University of Rio de Janeiro, Brazil Roman A
This review focus on the action of plant extracts, plant-derived compounds and synthetic drugs on effector functions of neutrophils
Quercetin, as well as described above gemichalcone A and gemichalcone B belong to flavonoids (Panche et al, 2016), which may indicate a specific chemical group of plant-derived compounds that modulate neutrophil degranulation
Summary
Echinacea pallida (nutt.) nutt Anacyclus pyrethrum (L.) lag Santolina chamaecyparissus L Baccharis dracunculifolia DC. Ghule et al (2006) Chang et al (1997) Miyazaki et al (2005) Sudam et al (2017) Sudam et al (2017) t Hart et al (1990) Kakalij et al (2014) Sudam et al (2017) Shukla et al (2009) Solanki and Jain, (2010) Toshkova et al (2004) Fidan et al (2008) Mukherjee et al (2005) Toiu et al (2019) (Continued on following page)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
