Abstract
Receptor-mediated phagocytosis is a complex process that mediates the internalization, by a cell, of other cells and large particles; this is an important physiological event not only in mammals, but in a wide diversity of organisms. Of simple unicellular organisms that use phagocytosis to extract nutrients, to complex metazoans in which phagocytosis is essential for the innate defence system, as a first line of defence against invading pathogens, as well as for the clearance of damaged, dying or dead cells. Evolution has armed multicellular organisms with a range of receptors expressed on many cells that serve as the molecular basis to bring about phagocytosis, regardless of the organism or the specific physiological event concerned. Key to all phagocytic processes is the finely controlled rearrangement of the actin cytoskeleton, in which Ca(2+) signals play a major role. Ca(2+) is involved in cytoskeletal changes by affecting the actions of a number of contractile proteins, as well as being a cofactor for the activation of a number of intracellular signalling molecules, which are known to play important roles during the initiation, progression and resolution of the phagocytic process. In mammals, the requirement of Ca(2+) for the initial steps in phagocytosis, and the subsequent phagosome maturation, can be quite different depending on the type of cell and on the type of receptor that is driving phagocytosis. In this review we discuss the different receptors that mediate professional and non-professional phagocytosis, and discuss the role of Ca(2+) in the different steps of this complex process.
Highlights
It has been brought to the attention of the Editorial Board that a portion of the text in the above Review Article was used without appropriate reference to the original source from Dr Melendez’s previous publication in 2005 entitled ‘Calcium Signaling during Phagocytosis’ appearing in Molecular Mechanisms of Phagocytosis [Chapter 9, pp. 117–132. (Rosales, C., ed.), Springer, Science]
Following an investigation by the National University of Singapore into the publications of A.J. Melendez, it has been brought to the attention of the Editorial Board that a portion of the text in the above Review Article (the first six sentences of the Introduction) was used without appropriate reference to the original source from Dr Melendez’s previous publication in 2005 entitled ‘Calcium Signaling during Phagocytosis’ appearing in Molecular Mechanisms of Phagocytosis [Chapter 9, pp
Summary
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
