Abstract
The metabolism of 25-hydroxyvitamin D 3 [25(OH)D 3] was examined in several phagocytic cells including alveolar macrophages and myeloid leukemia cells (M1, HL-60 and U937). Phagocytic cells converted 25(OH)D 3 to 10-oxo-19-nor-25-hydroxyvitamin D 3 and a new metabolite. The former metabolite was dominant in shorter incubation periods (1 h), whereas the latter dominated over longer incubation periods (24 h). The new metabolite was produced from 25(OH)D 3 directly but not through 10-oxo-19-nor-25-hydroxyvitamin D 3. The new metabolite was unequivocally identified as 8α,25-dihydroxy-9,10-seco-4,6,10(19)-cholestatrien-3-one. These results suggest that phagocytic cells somehow promote oxidation of the triene part of vitamin D compounds.
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