Abstract
Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng etal. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F.nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.
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