Abstract
In this article are reviewed the promising uses of phage display in the areas such as microbial pathogens detection of and vaccination. Phage display is a molecular technique by which foreign proteins are expressed at the surface of phage particles. Such phages thereby become vehicles for expression that not only carry within them the nucleotide sequence encoding expressed proteins, but have also the capability to replicate. Recent data acquired from genome sequencing and advances in phage biology research have aided the development of phage-derived bacterial detection and treatment strategies.
Highlights
This review aims to provide an insight into how an understanding of phage biology can be exploited to generate novel bacterial detection and vaccination strategies
According to here reviewed information about phage display, this technique/tool has a multipurpose utilization in molecular evolution, analysis of protein/ligand interactions and the generation of antibodies
Taking into account a prevention against pathogenic microorganisms, phage display could be used as a potential vaccine against Streptococcus agalactiae, a well-known bovine mastitis pathogen of particular importance because it is highly infectious, and causes mainly subclinical infections
Summary
Phages are either virulent (lytic) or temperate and use the host bacterium as a factory for their own replication Since their independent discovery by Twort and d’Herelle, research on phage has enabled major fundamental and technological advances that have been essential for the emergence of modern molecular biology (MCAULIFFE et al, 2007). Sequence analysis indicates that up to 20% of each bacterial genome might consist of phage-related DNA in the form of prophage or phage remnants (CASJENS, 2003). The importance of these phage-related sequences in the evolution of bacteria is most striking in the phenomenon of lysogenic conversion. This review aims to provide an insight into how an understanding of phage biology can be exploited to generate novel bacterial detection and vaccination strategies
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