Abstract
The effect of phytohaemagglutinin (PHA) stimulated spleen cells to Ehrlich ascites tumor cells in DDY mice was studied in vivo.3H-thymidine uptake of mouse spleen cells was enhanced by stimulation of PHA, and the mean value was 27.5. Also, cytotoxicity (51Cr release assay) of spleen cells against Ehrlich tumor cells was enhanced by stimulation of PHA and the mean value was 9.72±2.36%. PHA stimulated spleen cells and Ehrlich tumor cells, administered into the mouse abdominal cavity, had anti-tumor effects with marked inflammatory changes on the visceral peritoneum. However mouse survivals were not significantly different from those in controls. It is postulated that the inflammation was induced by the chemical mediators derived from the tumor-lymphocyte reaction. The growth of Ehrlich tumor cells was inhibited by PHA stimulated spleen cells which were subcutaneously administered. When spleen cells from the tumor-bearing mice were subcutaneously inoculated with tumor cells, the tumors were taken by the animals at a high rate, which suggested the presence of suppressor T cells.
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