PH Triggered In-situ Gelling Ophthalmic Drug Delivery System

Abstract

Eyes are delicate and most vital organs of the body whose defence mechanism restricts entry of exogenous substance. Conventional drug delivery systems get washed off within a short period of time that usually cause poor bioavailability and therapeutic responses because high tear fluid turnover and dynamics cause rapid elimination of the drug from the eye. In-situ gelling ophthalmic drug delivery system is one of the new methods that is developed to overcome this bioavailability problems. In-situ gelling systems are viscous polymerbased liquids that exhibit sol-to-gel phase transition on the ocular surface due to a change in a specific physicochemical parameter like temperature, ionic strength, or pH triggered in-situ systems. Using this formulation of pH triggered in-situ gel systems, the release of drug can be sustained for longer periods of time, therapeutically more efficacious, non-irritant and stable than conventional eye drops.