Abstract
In this work, new class of supramolecular copolydendrimers (SCDs) consisting of polyamidoamines (PAMAMs) and polyglycerol were synthesized through host-guest interactions. SCDs were able to encapsulate, transport, and release doxorubicin (DOX) efficiently. Host-guest interactions between PAMAM and polyglycerol was depended on pH so that aqueous solutions of SCDs and SCDs-based drug delivery systems were stable at room temperature and pH = 7.4, but their building blocks were separated in lower pHs(<pH = 5.5). This property was used for controlled release of DOX molecules from SCDs. Loading capacity of SCDs was depended on the generation of PAMAM and also number of attached polyglycerols on its periphery. According to spectroscopy and microscopy evaluations, size of SCDs and SCDs-based drug delivery systems was 114 and 129 nm, respectively. Due to their own fluorescence, drug delivery systems could be studied either by following encapsulated DOX molecules or SCDs.
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