PH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems.

Younghyun Shin,Yohan Kim,Dajung Kim,Seunho Jung,Moo Sung Kim,In Ki Hong,Yiluo Hu

doi:10.3390/polym13183197

Younghyun Shin, Yohan Kim + Show 5 more

Open Access

https://doi.org/10.3390/polym13183197

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Journal: Polymers	Publication Date: Sep 21, 2021
Citations: 18	License type: CC BY 4.0

Affiliation: Konkuk University, Kolmar Korea (South Korea)

Abstract

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

Highlights

Hydrogels are a three-dimensional hydrophilic polymer capable of absorbing large amounts of water [1]. Due to their unique properties, hydrogels are widely used in pharmaceutical, tissue engineering, biomedical, cosmetic, and drug delivery systems [2,3,4,5,6]
The coordination of the Fe3+-crosslinked layered SG/Carboxymethyl cellulose (CMC) interpenetrating polymer network (IPN) hydrogels were confirmed through Fourier Transform Infrared (FTIR) analysis
The FTIR spectrum of CMC showed a broad absorption band at 3408 cm−1, which was related to the stretching frequency of the –OH group, and the peaks at 1625, 1422, and 1076 cm−1 were related to the asymmetric, symmetric stretching vibrations of the carboxylate groups, and C–C

Summary

Introduction

Hydrogels are a three-dimensional hydrophilic polymer capable of absorbing large amounts of water [1]. Due to their unique properties, hydrogels are widely used in pharmaceutical, tissue engineering, biomedical, cosmetic, and drug delivery systems [2,3,4,5,6]. Natural polymers and synthetic polymers are used to manufacture hydrogels. Compared to synthetic-based polymers, natural polymers tend to be environmentally friendly, reproducible, and biocompatible [7]. Acidic bacterial polysaccharide-based hydrogels have a very wide application field because they can successfully perform drug delivery depending on the pH [13]

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