Abstract
The pH-responsive hydrogel was synthesized through an eco-friendly free radical polymerization process, utilizing ionic acid (IA), N, N-dimethyl acrylamide (DAAm), and double-bond modified vanillin (VMA). The P(DAAm-co-IA-co-VMA) hydrogel exhibited favorable compressive strength, swelling behavior, temperature sensitivity, pH sensitivity, salt solution sensitivity, and biocompatibility. Additionally, the study investigated the influence of varying IA monomer content on these properties. The evaluation of drug loading and release capabilities utilized 5-fluorouracil (5 Fu) as the model medicinal. The results showed that the P(DAAm-co-IA-co-VMA) hydrogel's cumulative release percentage was greater in the simulated intestinal fluid compared to the simulated gastric fluid, indicating its potential for oral drug delivery applications.
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