PH-Response controlled release system based on hollow mesoporous silica nanoparticles

Abstract

Compared with the conventional mesoporous silica materials, hollow structured mesoporous silica materials can loaded more drug molecules due to the large surface area and the total pore volume, which have an extensive application prospect in the field of drug controlled release. In this paper, the hollow structured mesoporous silica nanoparticles with controllable particle size and shell thickness was successfully synthesized by a modified template method. The hollow structured mesoporous silica nanoparticles were characterized by transmission electron microscopy (TEM), small angle X-ray scattering analysis (SAXS), nitrogen adsorption-desorption analysis, and the optimum preparation conditions was obtained. Furthermore, it had a comparative study to evaluate the effects of the obtained hollow mesoporous silica and ordinary mesoporous silica on the ability of drug release. The two samples loaded a certain amount of dye molecules of rhodamine B (RhB), and then the modification lysozyme molecules in the surface designed as a molecular switch. The two pH-response controlled release system was constructed in order to evaluate the corresponding loading contents. The drug release rate was investigated by monitoring the changed of fluorescence intensity at 575 nm (RhB). During the same period, more dye molecules released from the hollow structured mesoporous silica materials than the conventional mesoporous silica materials.