PH Metric Studies of Interaction of Synthesized Ligands 2-amino-4-hydroxy-6-methylpyrimidine and 1-(4-hydroxy-6-methylpyrimidino)-3-phenylthiocarbamide with Cu(II), Cd(II), Cr(II), Cations At 0.1 M Ionic Strength

D T Tayade ,Rahul Ashokrao Bhagwatkar,Neha A Bhagwatkar,D A Pund ,Dinesh B Rathod

doi:10.5539/ijc.v3n1p36

Abstract

Guanidine was successfully interacted with acetoacetic ester to synthesize 2-amino-4-hydroxy-6-methylpyrimidine(L1) which on further treatment with phenylisothiocyanate furnishes1-(4-hydroxy-6-methylpyrimidino)-3-phenylthiocarbamide (L2). The interactions of Cu(II), Cd(II), Cr(II) metal ionswith L1 and L2 have been studied at 0.1 M ionic strength in 70 % Dioxane-water mixture by Bjerrum method asadopted by Calvin and Wilson, It is observed that Cu(II), Cd(II), Cr(II) metal ions form 1:1 and 1:2 complexes withligands (L1 and L2). The data obtained were used to estimate and compare the values of proton-ligand stabilityconstant (pK.) and metal-ligand stability constants (log k).The effect of substituents were studied from estimateddata (pK & log k).

Highlights

Pyrimidino and thiocarbamido nucleus containing heterocycles possesses pharmaceutical, medicinal agricultural industrial and biotechnological significance(Barnes, D
From the titration curves, it is observed that the departure between acid + ligand (A+L) curve and acid + ligand + metal (A+L+M) curve for all systems started from pH = 3.0
This indicated the commencement of complex formation

Summary

Introduction

Pyrimidino and thiocarbamido nucleus containing heterocycles possesses pharmaceutical, medicinal agricultural industrial and biotechnological significance(Barnes, D. The manifold research work has been done on the study of metal and nitrogen heterocyclic ligands containing complexes(Irving H, 1954; Martell, 1962). The studies of metal-ligand complexes in solution having number of metal ions with ligands carboxylic acids, oximes, phenols etc. Irving and Williams had studied the order of stability of metal complexes of transition metal ions by comparing the ionic radius and second ionization potentials of metal ions, as it is valid for most nitrogen and oxygen donor ligands. Narwade et al (1985) have investigated metal-ligand stability constants of some lanthanides with some substituted sulphonic acids. Prasad et al (2005) have studied mixed ligand complexes of alkaline earth metals, Mg(II). Thakur et al (2010) studied the interaction between some lanthanide and radioactive metal ion with substituted Schiff’s bases at 0.1 M ionic strength pH metrically and spectrophotometrically

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