Abstract
Theranostic photodynamic nanomaterials suffer from poor water solubility and nontargeted toxicity. A water-soluble graphitic-phase carbon nitride-based material (g-C3 N4 ) conjugated to a positively charged porphyrin P2 (conjugating concentration: 60 μm mg-1 mL-1 ) is shown to be a new concept of photodynamic therapeutic agent (g-C3 N4 -P2). The pH-sensitive emission of g-C3 N4 is the driving force for the generation of 1 O2 from g-C3 N4 -P2. The amount of 1 O2 /light generated from a photosensitizer porphyrin can be controlled by the pH-sensitive emission of g-C3 N4 at acidic pH (pH 4-6), especially under acidic conditions mimicking those of tumor tissue, and thus has the potential to be utilized as a cancer-selective PDT agent.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
