Abstract
In order to achieve a controlled release drug delivery system (DDS) for cancer therapy, a pH and redox dual-responsive mesoporous silica nanoparticles (MSN)-sulfur (S)-S- chitosan (CS) DDS was prepared via an amide reaction of dithiodipropionic acid with amino groups on the surface of MSN and amino groups on the surface of CS. Using salicylic acid (SA) as a model drug, SA@MSN-S-S-CS was prepared by an impregnation method. Subsequently, the stability, swelling properties and drug release properties of the DDS were studied by x-ray diffraction, scanning electron microscopy, Fourier transform infrared microspectroscopy, size and zeta potential as well as Brunauer–Emmett–Teller surface area. Pore size and volume of the composites decreased after drug loading but maintained a stable structure. The calculated drug loading rate and encapsulation efficiency were 8.17% and 55.64%, respectively. The in vitro drug release rate was 21.54% in response to glutathione, and the release rate showed a marked increase as the pH decreased. Overall, double response functions of MSN-S-S-CS had unique advantages in controlled drug delivery, and may be a new clinical application of DDS in cancer therapy.
Highlights
Various chemotherapeutics have been exploited for effective cancer treatments
The mesoporous silica nanoparticles (MSN)-SS-CS material was synthesized by the amide reaction of the dithiodipropionic acid with the amino group on the surface of MSN and the amino group on the surface of CS
The characterization analysis showed that the MSN-SS-CS composite was successfully synthesized, and the drug was successfully loaded and encapsulated
Summary
Various chemotherapeutics have been exploited for effective cancer treatments. Nano-drugs have controlled release or targeting, which may alleviate the serious side effects of cytotoxic chemotherapeutic drugs to a certain extent [1,2,3,4]. Mesoporous materials have an ordered pore structure and a high specific surface area, which can provide a structure capable of accommodating a large number of drugs [5]. An ordered pore network can appropriately control the loading and release of drugs. These advantages have attracted attention in the field of application of drug delivery systems (DDS) [6,7]. Among various mesoporous materials [8,9,10], the unique mesopore structures [11]
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