Abstract
In order to achieve the effective therapy of cancer through targeting and synergistic strategy, methyl-capped poly(ethylene glycol)-poly(caprolactone) block copolymers modified with imine and disulfide bonds (mPEG-imine-SS-PCL) was designed and synthesized, which encapsulated the therapeutic agent, doxorubicin (DOX) and oleic acid-coated bismuth sulfide nanodots (OA-Bi2S3), into the hydrophobic core to form composite micelles by self-assembly in aqueous solution. The imine and disulfide bonds in the composite micelles structure remain stable in the normal physiological environment, but can be broken in the weakly acidic and reducing tumor micro-environment, causing disruption of the micelle structure and release of the therapeutic agent for chemo-photothermal synergistic therapy.
Published Version
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