Abstract
Drug delivery system (DDs) should include stimuli-responsive release at the target sites. With this goal, pH and Glutathione (GSH) microenvironment triggering mesoporous silica nanoparticles (MSNs) were prepared. In this system, the ZnO Quantum Dots, as a gatekeeper is bonded to the silica nanocarrier via a cleavable disulfide bond. ZnO QDs have the potential to be used as a gatekeeper due to, its acidic dissolution to Zn 2+ ions. Doxorubicin hydrochloride (Dox), an effective chemotherapeutic drug, is used to investigate the release behavior. Under physiological pH, ZnO QDs is stable, which resulted in blocked drugs inside the pores. Under the acidic pH, grafted ZnO QDs is removed due to its acidic dissolution, which resulted in the pore opening and releasing of the drug. Besides pH stimuli, the release of the drug was triggered by GSH.
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