Abstract
BackgroundBreast cancer is highly prevalent globally and is one of the main causes of cancer-related deaths worldwide. Despite the advances, more insights are needed to decipher the regulatory mechanisms leading to breast cancer development and progression. Here, we examined the expression of PGR and TUG1 genes in breast cancer. Material and methodsqPCR was used to quantitatively measure the expression of PGR and TUG1 transcripts in normal and breast cancer fresh clinical samples. ResultsThe higher expression of both PGR and TUG1 was observed in the breast tumors as compared to the normal adjacent paired samples. The ROC curve analysis revealed that PGR and TUG1 expression patterns can discriminate breast tumor samples against normal tissues. Besides, there was a significant correlation between PGR and TUG1 expression in the studied samples. ConclusionPGR and TUG1 are significantly up-regulated in breast cancer, which both can distinct tumor from normal tissues. With respect to the positive correlation between PGR and TUG1, this gene signature might be used as a diagnostic biomarker for breast cancer detection.
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