Abstract
1.1. Rat epidydimal fat pads and isolated fat cells release arachidonic acid as well as prostaglandin E2 during lipolysis.2.2. The enzyme system converting suitable essential fatty acids into prostaglandins E is present in adipose tissue of rat and ram and in isolated fat cells.3.3. Low concentrations of prostaglandin E1, prostaglandin E2 and ω-homoprostaglandin E1 efficiently inhibit stimulated lipolysis; biologically inactive prostaglandins E have no such effect in comparable concentrations.4.4. In essential fatty acid-deficient adipose tissue of the rat there is a decreased release of prostaglandin E2, an increase in lipolysis and a pronounced inhibition of the stimulated lipolysis by added prostaglandin E.5.5. These observations are compatible with a physiological role of prostaglandins E in the regulation of lipolysis, possibly by a feed-back mechanism.
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