Abstract
Pfhrp2 Deletions in the Democratic Republic of Congo: Evidence of Absence, or Absence of Evidence?
Highlights
To the Editor—Parr et al report that Plasmodium falciparum parasites with deletion of the pfhrp2 gene can be found in children across all provinces of the Democratic Republic of Congo [1]
Parr et al used many of these recommended steps, and the work was clearly undertaken to a high technical standard, but a distinct feature of the study was that the diagnosis of P. falciparum was determined by real-time polymerase chain reaction (PCR) detection of pfldh, a relatively sensitive approach designed to capture all pfhrp2-deleted parasites
The article comes to a confident conclusion that the pfhrp2-negative PCR results represent gene deletion rather than insufficient DNA
Summary
8. Murillo Solano C, Akinyi Okoth S, Abdallah JF, et al Deletion of Plasmodium falciparum histidine-rich protein 2 (pfhrp2) and histidine-rich protein 3 (pfhrp3) genes in Colombian parasites. Rapid diagnostic tests failing to detect Plasmodium falciparum infections in Eritrea: an investigation of reported false negative RDT results.
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