PF475 PROGNOSTIC VALUE OF METABOLIC TUMOR VOLUME AND TOTAL LESION GLYCOLYSIS CALCULATION ON BASELINE 18F‐FDG‐PET‐CT IN PATIENTS WITH HODGKIŃS LYMPHOMA AND ITS CORRELATION WITH CLINICAL CHARACTERISTICS

Abstract

Background:Hodgkin Lymphoma is a neoplasm with remission high rates with conventional therapy, however 20% does not respond or has relapsing disease. Multiple strategies have been investigated to predict the outcomes to treatment, one of them is interim PET CT to predict progression free survival (PFS). Other parameters that can be measured are total lesion glycolysis (TLG) and metabolic tumor volume (TMV), which might provide useful prognostic information at diagnosis that in the future could be the base for new risk assesment models.Aims:To assess the prognostic value of TMV and TLG measured by 18FFDG PET‐CT at the time of diagnosis of HL and its relation to PFS.Methods:It was selected patients with recent diagnosis of HL between 2009–2015 in the National Institute of Oncology, with a PET CT at diagnosis. It was calculation of TMV and TLG at time of diagnosis using the syringo.via V8108 software. To define the optimal cutoff the ROC curve was established using SPSS software and Kapla‐Meier curves were generated for survival analysis followed by the long rank test.Results:We identified 144 patients, 11 were excluded do to loss of follow up. With male predominance (53%). Median age was 36 years (16–83). The most of patients had advanced disease (70%). All patients received AVBD and 74% radiotherapy as consolidation. Complete remission was 80%. According ROC curves the cutoff for TLG was 2650 cm3. The clinical differences between patients with high TGL has been showed in Fig 1. The median follow‐up was 54 months (4–115), 5 years OS and PFS were 82.5% and 70% respectively. High TLG was a significant prognostic factor with 5y PFS 62% vs 76% (p = <0.05). There was no difference in OS. In the univariate analysis other prognostic factor for PFS were extraganglionar disease (p = 0.045) and IPS prognostic scale above 3 points (p = 0.01). The cutoff for MTV was 350 cm3, however high MTV was not related to worse prognosis.Summary/Conclusion:In our population the cutoff for TLG were 2650 cm3 associated to lower PFS and more tumor burden. MTV was not associated with lower PFS as previous reports. Furthermore, there is a strong correlation between this results and clinical characteristics, thus, it can be used as a strategy to decide the first treatment line.image