Abstract
Gene-knock-out studies implicate roles of lymphotoxin (LT) α β and LT βR in the initial phase of Peyers patch (PP) organogenesis. We recently identified the requirement of IL-7R α/ γc/Jak3 signal in LT α β production of IL-7R α + cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7R α, which then stimulate the IL-7R α + cells to produce LT α β, activating the LT βR + cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.
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