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Abstract
Khellin, a furochromone structurally related to furocoumarins, is a phototherapeutic agent used against psoriasis and vitiligo. This paper reports that pretreatment of HeLa cells with pertussis toxin reverses both the inhibition of NaF-stimulated adenylyl cyclase activity and the stimulation of GTPase by khellin alone and plus UVA light, as previously reported. Our results demonstrate, for the first time, the khellin is able to elicit an intracellular response by Giα protein.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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