Abstract
A kinetic study of the effects of lithium on iodine metabolism in hyperthyroidism is reviewed. The analysis, carried out in collaboration with Mones Berman, disclosed several unexpected findings. In addition to the inhibition of thyroid iodine release predicted by animal studies, an apparent decrease in extrathyroidal iodine disappearance was observed. This was confirmed by a direct study of the metabolic clearance of labeled thyroxine in hyperthyroid subjects. In euthyroid subjects, lithium did not alter thyroxine disappearance. Also unexpectedly, the lithium-induced perturbations did not promptly return to the control state after the serum lithium level had become undetectable. This suggested a delayed release of lithium from extravascular pools, a phenomenon later described in bone. These findings demonstrated the power of kinetic modeling when used as an analytical tool.
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