Perturbations de l'activité bioélectrique de l'hippocampe de la souris, induites par l'acetoxycycloheximide

Abstract

Swiss male mice were chronically implanted with electrodes in dorsal hippocampus and in mesencephalon (mesencephalic reticular formation and central gray). Effects of acetoxycycloheximide (AXM) on spontaneous bioelectrical activity of the hippocampus and on hippocampal response to mesencephalic stimulation were analyzed. AXM injection (7 mg/kg) provoked a decrease in both frequency and amplitude of the spontaneous hippcampal activity and, in particular, a marked decrease in the theta activity in the 6–10 cps band. AXM induced no change in the mesencephalic stimulation threshold shown to induce hippocampal theta rhythm. A decrease in both frequency and amplitude of the theta rhythm induced by mesencephalic stimulation was, however, recorded. These alterations, which appeared during the first hour following AXM injection, were especially obvious from 3 to 6 hours after treatment. From 7 to 24 hours after injection, the hippocampal bioelectrical activity, either spontaneous or induced, recovered gradually its initial characteristics.