Abstract
The expression profiles of umbilical cords from premature newborns reveal distinct patterns, including changes in the expression of chromatin remodeling factors, associated with the development of bronchopulmonary dysplasia.
Highlights
One-third to one-half of all infants born before the 28th week of gestation develop bronchopulmonary dysplasia (BPD)
The lung disorder bronchopulmonary dysplasia (BPD) occurs in 20% to 40% of infants born at under 1,000 g and before 28 completed weeks of gestation [1,2,3,4] and it is the second leading cause of death among infants born within this gestational age [5]
In this study we have explored this hypothesis by examining the relationships between human gene expression in the umbilical cord at the time of birth and subsequent BPD, defined as the requirement for supplemental oxygen at 36 weeks postmenstrual age
Summary
One-third to one-half of all infants born before the 28th week of gestation develop bronchopulmonary dysplasia (BPD). To evaluate the feasibility of using expression profiling in umbilical cord tissue to discover molecular signatures for developmental staging and for determining risk of BPD, we conducted a cross-sectional study of infants born at less than 28 weeks of gestation (n = 54). Identified prenatal factors that are associated with the development of BPD include surfactant deficiency and maternal infection, including chorioamnionitis. Inflammatory mediators, including cytokines and growth factors, appear to be involved in the development of BPD [7], and their activity can be upregulated by inflammatory processes that might begin prenatally and affect the fetus via the placenta [6,8]. Chorioamnionitis and funisitis are accompanied by alterations in the expression of inflammatory mediators [9]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
