Abstract
Seven-day-old C57BL/10 mice injected with 3 X 10(6) normal adult lymph node cells (NAL) from syngeneic donors were compared with uninjected littermates when 5 to 7 wk old. The direct PFC response to sheep erythrocytes was suppressed by 60%. Responses to PHA and Con A but not LPS were suppressed by 60 to 90%. Primary and secondary (after skin graft rejection) MLR responses were suppressed by 30 to 40%. Active suppressor cells were demonstrable in these mice. Skin grafts incompatible for H-2 were rejected in normal time. NAL derived from adult mice conferred the effect, but not cells from 7-day-old donors. Mice inoculated with Rous sarcoma virus within the 1st day of life and 3 X 10(6) NAL at 7 days of age displayed up to 5-fold increased incidence of primary sarcomas.
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