Perturbation-Based Mapping of Subcallosal Cingulate With Deep Brain Stimulation: Cortical Oscillatory Dynamics to Confirm Target for Electrical Neuromodulation

Allison Waters,Ezra E Smith,Ki Seung Choi,Ashan Veerakumar,Mosadoluwa Obatusin,Andrea Crowell,Patricio Riva-Posse,Martijn Figee,Helen Mayberg

doi:10.1016/j.biopsych.2020.02.824

Perturbation-Based Mapping of Subcallosal Cingulate With Deep Brain Stimulation: Cortical Oscillatory Dynamics to Confirm Target for Electrical Neuromodulation

Allison Waters, Ezra E Smith + Show 7 more

https://doi.org/10.1016/j.biopsych.2020.02.824

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Journal: Biological Psychiatry

Publication Date: May 1, 2020

Affiliation: Icahn School of Medicine at Mount Sinai, New York State Psychiatric Institute, Emory University

#Dense Array EEG #Subcallosal Cingulate + Show 8 more

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Abstract

Perturbation-based mapping is an emerging approach to the study of circuit dynamics in the living human brain. Pulses of deep brain stimulation (DBS) to the subcallosal cingulate (SCC) evoke a coherent and reliable cortical response, recorded on the scalp surface with dense array EEG, that may reflect endogenous network dynamics. As precision targeting within the SCC region has been linked to DBS treatment efficacy, we examined features of the cortical perturbation map that change when stimulation is delivered to different locations within the surgical target region.

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